P0300 on a Lexus: Causes, Fixes & Repair Cost

🟠 Moderate severity · drivable

If the check engine light is flashing, stop driving — a severe misfire can damage the catalytic converter. A steady light is usually safe for a short drive to a shop.

What P0300 means on a Lexus

On a Lexus, P0300 means the engine computer sees misfires jumping between cylinders instead of on one fixed cylinder. A misfire means a cylinder is not burning its fuel properly, which wastes gas and can damage the catalytic converter if left alone.

Is P0300 common on Lexuss?

P0300 shows up on Lexus models at high mileage, such as the ES 350, RX 350, and IS with the 2GR-FE 3.5L V6. Worn spark plugs and failing ignition coils are the top causes. The 3.5L V6's rear bank plugs and coils are harder to reach, which pushes up repair labor costs.

Commonly reported on: ES 350, RX 350, IS 350, GX 460.

Symptoms

Check engine light on (flashing if severe)
Rough idle or shaking engine
Loss of power or hesitation
Poor fuel economy

Common causes

most common: Worn or fouled spark plugs
common: Failing ignition coils
common: Vacuum leak
less common: Clogged fuel injectors
less common: Low compression from engine wear

How to fix it

Fix	DIY?	Typical cost
Replace worn spark plugs	Yes	$80–300
Replace failing ignition coils	Yes	$100–400
Find and repair vacuum leaks	Yes	$10–100
Run a compression test to rule out internal engine wear	Mechanic	$100–200